Adverse Drug Reaction Classification System

         

ADR Ontology
ADR Term Hepatic necrosis
ADR ID BADD_A02009
ADR Hierarchy
09      Hepatobiliary disorders
09.01      Hepatic and hepatobiliary disorders
09.01.07      Hepatocellular damage and hepatitis NEC
09.01.07.002      Hepatic necrosis
Description A disorder characterized by a necrotic process occurring in the hepatic parenchyma. [CTCAE]
MedDRA Code 10019692
MeSH ID Not Available
ADR Severity Grade (FAERS)
ADR Severity Grade (CTCAE)
Synonym
Acute and subacute necrosis of liver | Hepatic lobule necrosis | Hepatic necrosis | Hepatic necrosis extensive | Hepatitis necrotizing | Liver necrosis | Necrosis hepatocellular | Necrosis liver | Necrosis liver focal | Subacute hepatic necrosis | Hepatitis necrotising
Drugs Leading to the ADR
Drug IDDrug NameADR Frequency (FAERS)ADR Severity Grade (FAERS)
BADD_D00535Crizotinib0.000533%
BADD_D00555Cyproterone acetate--
BADD_D00568Dacarbazine--
BADD_D00611Desflurane--
BADD_D00648Diazepam0.000111%
BADD_D00653Diclofenac0.000077%
BADD_D00686Diphenhydramine0.000505%
BADD_D00695Disulfiram--
BADD_D00723Doxorubicin0.000347%
BADD_D00749Efavirenz0.008776%
BADD_D00770Enflurane--
BADD_D00809Escitalopram--
BADD_D00810Escitalopram oxalate--
BADD_D00850Etodolac--
BADD_D00858Everolimus0.000381%
BADD_D00908Floxuridine--
BADD_D00912Fluconazole--
BADD_D00913Flucytosine--
BADD_D00929Fluorometholone--
BADD_D00932Fluoxetine--
BADD_D00933Fluoxetine hydrochloride--
BADD_D00943Flutamide--
BADD_D00948Fluvastatin--
BADD_D00949Fluvastatin sodium--
BADD_D00952Folic acid0.000092%
BADD_D00965Fosfomycin--
BADD_D00966Fosfomycin tromethamine--
BADD_D00981Gabapentin0.000102%
BADD_D01009Gemcitabine0.000208%
BADD_D01057Halothane--
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ADReCS-Target
ADR Term Drug Name Target